T16I (p.Thr16Ile) variant of ROS1 (P08922)
T16I (p.Thr16Ile) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
T16I (p.Thr16Ile) variant details
- p.Thr16Ile
- TOPMed rs1464664635
- gnomAD rs1464664635
- Missense
- Variant Prioritization Score for Impact Estimate 0.229
- REVEL 0.08
- MetaLR 0.10
- MetaSVM -1.01
- CADD 16.20
- PolyPhen-2 0.00
- SIFT 0.09
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available