S23F (p.Ser23Phe) variant of ROS1 (P08922)
S23F (p.Ser23Phe) in ROS1 (P08922) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
S23F (p.Ser23Phe) variant details
- p.Ser23Phe
- rs1562400768
- NCI-TCGA Cosmic COSV6385
- cosmic curated COSV63857
- Ensembl rs1562400768
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.47
- REVEL 0.44
- MetaLR 0.39
- MetaSVM -0.24
- CADD 25.60
- PolyPhen-2 0.88
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available