K35N (p.Lys35Asn) variant of ROS1 (P08922)
K35N (p.Lys35Asn) in ROS1 (P08922) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
K35N (p.Lys35Asn) variant details
- p.Lys35Asn
- TOPMed rs1776075507
- gnomAD rs1776075507
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.185
- REVEL 0.09
- MetaLR 0.09
- MetaSVM -0.90
- CADD 16.00
- PolyPhen-2 0.27
- SIFT 0.83
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available