G18S (p.Gly18Ser) variant of ROS1 (P08922)
G18S (p.Gly18Ser) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
G18S (p.Gly18Ser) variant details
- p.Gly18Ser
- gnomAD rs1435247456
- Missense
- Variant Prioritization Score for Impact Estimate 0.201
- REVEL 0.07
- MetaLR 0.13
- MetaSVM -0.93
- CADD 17.70
- PolyPhen-2 0.01
- SIFT 0.34
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available