C80W (p.Cys80Trp) variant of ROS1 (P08922)
C80W (p.Cys80Trp) in ROS1 (P08922) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes structural context.
C80W (p.Cys80Trp) variant details
- p.Cys80Trp
- rs1774738285
- ClinGen CA365447814
- ClinVar RCV004204099
- TOPMed rs1774738285
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.686
- AlphaMissense 0.85
- MetaLR 0.63
- MetaSVM 0.24
- PolyPhen-2 1.00
- SIFT 0.00
- EVE 0.88
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available