V12D (p.Val12Asp) variant of ROS1 (P08922)
V12D (p.Val12Asp) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
V12D (p.Val12Asp) variant details
- p.Val12Asp
- gnomAD rs1776082502
- Missense
- Variant Prioritization Score for Impact Estimate 0.381
- REVEL 0.31
- MetaLR 0.15
- MetaSVM -0.92
- CADD 8.48
- PolyPhen-2 0.12
- SIFT 0.09
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available