D68Y (p.Asp68Tyr) variant of ROS1 (P08922)
D68Y (p.Asp68Tyr) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
D68Y (p.Asp68Tyr) variant details
- p.Asp68Tyr
- gnomAD rs1285596214
- Missense
- Variant Prioritization Score for Impact Estimate 0.336
- REVEL 0.39
- MetaLR 0.21
- MetaSVM -0.74
- CADD 16.90
- PolyPhen-2 0.75
- SIFT 1.00
- Most common in the South Asian population (allele frequency 4.7e-05)
- Structural context available