P9L (p.Pro9Leu) variant of ROS1 (P08922)
P9L (p.Pro9Leu) in ROS1 (P08922) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
P9L (p.Pro9Leu) variant details
- p.Pro9Leu
- rs770579408
- ClinGen CA3976075
- cosmic curated COSV63862
- ClinVar RCV004449560
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0887
- REVEL 0.06
- MetaLR 0.02
- MetaSVM -1.03
- CADD 0.01
- PolyPhen-2 0.00
- SIFT 1.00
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available