W21C (p.Trp21Cys) variant of ROS1 (P08922)
W21C (p.Trp21Cys) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
W21C (p.Trp21Cys) variant details
- p.Trp21Cys
- Ensembl rs2128753371
- Missense
- Variant Prioritization Score for Impact Estimate 0.553
- REVEL 0.55
- MetaLR 0.40
- MetaSVM -0.16
- CADD 28.60
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available