C61Y (p.Cys61Tyr) variant of ROS1 (P08922)
C61Y (p.Cys61Tyr) in ROS1 (P08922) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.72 / 1. The record also includes population frequency data and structural context.
C61Y (p.Cys61Tyr) variant details
- p.Cys61Tyr
- TOPMed rs1020449619
- gnomAD rs1020449619
- Missense
- Variant Prioritization Score for Impact Estimate 0.722
- REVEL 0.76
- MetaLR 0.53
- MetaSVM 0.10
- CADD 26.10
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 9.7e-05)
- Structural context available