HLA-DPB1 (P04440) variants and mutations
HLA-DPB1 (also known as P04440) is a human protein-coding gene encoding a HLA class II histocompatibility antigen, DP beta 1 chain protein. It pairs with HLA-DPA1 to shape the peptide-binding groove used for antigen presentation to CD4 T cells. Extensive polymorphism strongly influences immune recognition and is clinically important in transplantation, autoimmune disease, infection, and selected drug hypersensitivities. This analysis covers 585 HLA-DPB1 variants and mutations. Of these, 83% have computational variant effect predictions. Disease context includes type 1 diabetes mellitus, rheumatoid arthritis, and systemic sclerosis. Example HLA-DPB1 variants include M1?, M2I, and M2T.
Variant analysis overview
- Gene: HLA-DPB1
- Protein: P04440
- UniProt accession: P04440
- Organism: Homo sapiens
- Variants analyzed: 585
- Variant scope: all variants
- Completed: 2026-08-20
Variant and mutation evidence
- Variant composition: 357 unspecified-consequence records; 111 missense variants; 32 frameshift variants; 65 synonymous variants; 7 in-frame deletions; 5 stop-gained variants; 1 splice-region variants; 5 in-frame insertions; 2 protein altering variant
- Prediction scores: 488 variants have prediction scores (83% of the analyzed set).
Clinical, disease, and population context
- Disease context: 25 disease associations are represented. Top associations: type 1 diabetes mellitus, rheumatoid arthritis, systemic sclerosis, acute lymphoblastic leukemia, neoplasm, myeloid sarcoma, cancer, cervical carcinoma, cervical cancer, breast cancer, myasthenia gravis, acute myeloid leukemia.
Protein structure and variant hotspots
- Protein features: 1 transmembrane segments; 1 domains; 1 post-translational modification sites.
- Structural context: 113 variants have structural context.
- PTM context: 1 variants overlap post-translational modification sites.
Data sources
Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.
Notable HLA-DPB1 variants
Examples include M1?, M2I, M2T, M2V, V3A, V3I, V3L, L4C. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.
- M1?, rs1167784257, NCI-TCGA Cosmic COSV1013, MetaLR 0.01, MetaSVM -1.00, Variant assessed as somatic; high impact.
- M2I (p.Met2Ile), TOPMed rs1169806514, gnomAD rs1169806514, REVEL 0.16, CADD 19.80
- M2T (p.Met2Thr), NCI-TCGA Cosmic COSV1013, Variant assessed as somatic; moderate impact.
- M2V (p.Met2Val), gnomAD 6-33076045-A-G, REVEL 0.16, CADD 0.81
- V3A (p.Val3Ala), Ensembl rs1762517659, REVEL 0.03, CADD 5.27
- V3I (p.Val3Ile), ExAC rs773568820, TOPMed rs773568820, gnomAD rs773568820, REVEL 0.07, CADD 18.70
- V3L (p.Val3Leu), ExAC rs773568820, TOPMed rs773568820, gnomAD rs773568820
- L4C (p.Leu4Cys), gnomAD 6-33076048-GT-G, CADD 18.10
- L4L (p.Leu4Leu), gnomAD 6-33076051-C-T, CADD 5.25
- Q5* (p.Gln5Ter), NCI-TCGA TCGA novel, Variant assessed as somatic; high impact.
- Q5L (p.Gln5Leu), gnomAD 6-33076055-A-T, REVEL 0.02, CADD 0.38
- Q5E (p.Gln5Glu), rs1023597820, gnomAD 6-33080490-C-G, CADD 3.24
- Q5K (p.Gln5Lys), gnomAD 6-33080490-C-A, CADD 3.04
- Q5H (p.Gln5His), gnomAD 6-33080492-G-T, CADD 7.31
- V6I (p.Val6Ile), gnomAD 6-33076057-G-A, REVEL 0.02, CADD 3.69
- V6A (p.Val6Ala), gnomAD 6-33076058-T-C, REVEL 0.05, CADD 8.50
- S7Y (p.Ser7Tyr), NCI-TCGA Cosmic COSV6960, Variant assessed as somatic; moderate impact.
- A8T (p.Ala8Thr), gnomAD rs1465636756
- A8V (p.Ala8Val), rs1332954676, gnomAD rs1332954676, NCI-TCGA Cosmic COSV1013, REVEL 0.03, CADD 0.01, Variant assessed as somatic; moderate impact.
- A8A (p.Ala8Ala), rs41540314, gnomAD 6-33076065-G-A, CADD 1.30
- A8S (p.Ala8Ser), rs1287188260, gnomAD 6-33080493-G-T, CADD 7.22
- A8D (p.Ala8Asp), gnomAD 6-33080494-C-A, CADD 4.76
- A9D (p.Ala9Asp), ExAC rs779921780, TOPMed rs779921780, gnomAD rs779921780, REVEL 0.10, CADD 3.98
- A9P (p.Ala9Pro), NCI-TCGA Cosmic COSV1013, Variant assessed as somatic; moderate impact.
- A9T (p.Ala9Thr), TOPMed rs1762518837
- A9V (p.Ala9Val), ExAC rs779921780, TOPMed rs779921780, gnomAD rs779921780, REVEL 0.04, CADD 2.56
- A9S (p.Ala9Ser), gnomAD 6-33076066-G-T, REVEL 0.03, CADD 0.57
- A9A (p.Ala9Ala), rs536111967, gnomAD 6-33076068-C-A, CADD 4.26
- P10T (p.Pro10Thr), gnomAD rs763314196, REVEL 0.14, CADD 10.40
- P10S (p.Pro10Ser), gnomAD 6-33076069-C-T, REVEL 0.11, CADD 7.71
- P10P (p.Pro10Pro), gnomAD 6-33076071-C-T, CADD 2.27
- P10A (p.Pro10Ala), gnomAD 6-33080523-C-G, CADD 5.58
- R11G (p.Arg11Gly), ExAC rs777782877, TOPMed rs777782877, gnomAD rs777782877, NCI-TCGA TCGA novel, REVEL 0.04, CADD 5.39, Variant assessed as somatic; high impact.
- R11Q (p.Arg11Gln), gnomAD rs1318704515, REVEL 0.04, CADD 6.07
- R11W (p.Arg11Trp), ExAC rs777782877, TOPMed rs777782877, gnomAD rs777782877, REVEL 0.04, CADD 2.45
- R11P (p.Arg11Pro), rs1048293876, gnomAD 6-33076066-G-GC, CADD 12.80
- R11R (p.Arg11Arg), rs2150366564, gnomAD 6-33076074-G-A, CADD 4.33
- R11K (p.Arg11Lys), gnomAD 6-33080500-G-A, CADD 6.20
- R11C (p.Arg11Cys), rs967951653, gnomAD 6-33080514-C-T, CADD 0.78
- R11S (p.Arg11Ser), rs967951653, gnomAD 6-33080514-C-A, CADD 0.58
- R11H (p.Arg11His), rs750089900, gnomAD 6-33080515-G-A, CADD 4.49
- T12P (p.Thr12Pro), TOPMed rs1200566458, gnomAD rs1200566458, REVEL 0.12, CADD 11.50
- T12S (p.Thr12Ser), TOPMed rs1200566458, gnomAD rs1200566458, REVEL 0.09, CADD 8.13
- T12R (p.Thr12Arg), gnomAD 6-33076076-C-G, REVEL 0.13, CADD 10.60
- T12T (p.Thr12Thr), gnomAD 6-33076077-A-T, CADD 4.63
- T12A (p.Thr12Ala), rs1762779620, gnomAD 6-33080511-A-G, CADD 6.72
- T12N (p.Thr12Asn), gnomAD 6-33080512-C-A, CADD 4.37
- T12I (p.Thr12Ile), rs1450574181, gnomAD 6-33080512-C-T, CADD 5.05
- V13A (p.Val13Ala), gnomAD 6-33076079-T-C, REVEL 0.06, CADD 1.79
- A14S (p.Ala14Ser), gnomAD 6-33076081-G-T, REVEL 0.03, CADD 8.14
- L15M (p.Leu15Met), ExAC rs771074929, TOPMed rs771074929, gnomAD rs771074929, REVEL 0.07, CADD 18.90
- L15V (p.Leu15Val), ExAC rs771074929, TOPMed rs771074929, gnomAD rs771074929, REVEL 0.04, CADD 11.60
- L15L (p.Leu15Leu), gnomAD 6-33076084-C-T, CADD 2.62
- L15F (p.Leu15Phe), gnomAD 6-33080519-A-T, CADD 8.07
- T16K (p.Thr16Lys), 1000Genomes rs41558014, ESP rs41558014, ExAC rs41558014, TOPMed rs41558014, REVEL 0.11, CADD 0.01, Benign, in allele DPB1*09:02
- T16M (p.Thr16Met), rs41558014, 1000Genomes rs41558014, ESP rs41558014, ExAC rs41558014, REVEL 0.02, CADD 0.00, Benign, not provided
- T16S (p.Thr16Ser), gnomAD 6-33076087-A-T, REVEL 0.04, CADD 5.29
- T16T (p.Thr16Thr), rs1211308370, gnomAD 6-33076089-G-A, CADD 1.92
- A17V (p.Ala17Val), NCI-TCGA TCGA novel, REVEL 0.07, CADD 4.31, Variant assessed as somatic; moderate impact.
- A17A (p.Ala17Ala), rs146214653, gnomAD 6-33076092-G-A, CADD 6.35
- L19P (p.Leu19Pro), NCI-TCGA TCGA novel, REVEL 0.11, CADD 23.70, Variant assessed as somatic; moderate impact.
- L19L (p.Leu19Leu), gnomAD 6-33076098-G-C, CADD 4.08
- M20I (p.Met20Ile), ExAC rs376742482, TOPMed rs376742482, gnomAD rs376742482, REVEL 0.08, CADD 11.80
- M20T (p.Met20Thr), ExAC rs770193215, TOPMed rs770193215, gnomAD rs770193215, REVEL 0.03, CADD 7.06
- V21E (p.Val21Glu), ExAC rs763465797, gnomAD rs763465797, REVEL 0.14, CADD 16.70
- L22M (p.Leu22Met), Ensembl rs1762522022
- L23P (p.Leu23Pro), gnomAD 6-33076107-G-GC, CADD 21.70
- T24A (p.Thr24Ala), ExAC rs763726124, gnomAD rs763726124
- T24I (p.Thr24Ile), rs11551416, UniProt VAR 060628, gnomAD rs11551416, REVEL 0.11, CADD 4.92
- T24P (p.Thr24Pro), ExAC rs763726124, gnomAD rs763726124, REVEL 0.05, CADD 8.35
- T24T (p.Thr24Thr), rs761566912, gnomAD 6-33076113-A-G, CADD 3.08
- S25C (p.Ser25Cys), ExAC rs751203807, TOPMed rs751203807, gnomAD rs751203807, REVEL 0.11, CADD 22.60
- S25F (p.Ser25Phe), gnomAD 6-33076115-C-T, REVEL 0.07, CADD 22.80
- S25Y (p.Ser25Tyr), gnomAD 6-33076115-C-A, REVEL 0.13, CADD 22.50
- S25S (p.Ser25Ser), gnomAD 6-33076116-T-G, CADD 5.05
- V27D (p.Val27Asp), gnomAD 6-33076121-T-A, REVEL 0.15, CADD 23.00
- V27V (p.Val27Val), rs139072161, gnomAD 6-33076122-C-T, CADD 9.15
- Q28H (p.Gln28His), gnomAD 6-33076125-G-C, REVEL 0.08, CADD 22.00
- G29A (p.Gly29Ala), rs759178727, gnomAD 6-33076122-C-CCAG, CADD 26.80
- G29D (p.Gly29Asp), gnomAD 6-33076127-G-A, REVEL 0.29, CADD 24.80
- G29G (p.Gly29Gly), gnomAD 6-33076128-C-A, CADD 9.12
- G29C (p.Gly29Cys), gnomAD 6-33080502-G-T, CADD 2.94
- G29R (p.Gly29Arg), gnomAD 6-33080502-G-C, CADD 3.08
- G29* (p.Gly29Ter), gnomAD 6-33080520-G-T, CADD 0.76
- G29E (p.Gly29Glu), rs1437398517, gnomAD 6-33080521-G-A, CADD 0.80
- R30K (p.Arg30Lys), ExAC rs755900839, gnomAD rs755900839, REVEL 0.15, CADD 18.30
- R30P (p.Arg30Pro), UniProt VAR 060629, Benign, in allele DPB1*75:01
- R30Q (p.Arg30Gln), gnomAD 6-33076124-A-AG, CADD 26.80
- R30G (p.Arg30Gly), gnomAD 6-33076129-A-G, REVEL 0.10, CADD 21.50
- R30W (p.Arg30Trp), gnomAD 6-33076129-A-T, REVEL 0.18, CADD 25.80
- A31L (p.Ala31Leu), UniProt VAR 060630, Benign, in allele DPB1*75:01
- A31T (p.Ala31Thr), gnomAD rs1360699922, REVEL 0.04, CADD 17.70
- A31S (p.Ala31Ser), gnomAD 6-33076132-G-T, REVEL 0.03, CADD 20.30
- A31D (p.Ala31Asp), gnomAD 6-33076133-C-A, REVEL 0.11, CADD 10.60
- A31V (p.Ala31Val), gnomAD 6-33076133-C-T, REVEL 0.06, CADD 20.30
- A31A (p.Ala31Ala), gnomAD 6-33076134-C-T, CADD 9.97
- T32P (p.Thr32Pro), UniProt VAR 060631, Benign, in allele DPB1*75:01
- T32H (p.Thr32His), gnomAD 6-33076132-G-GC, CADD 24.00
- T32L (p.Thr32Leu), gnomAD 6-33076132-GC-G, CADD 23.10
- T32S (p.Thr32Ser), gnomAD 6-33076135-A-T, REVEL 0.03, CADD 11.70
- T32N (p.Thr32Asn), gnomAD 6-33076136-C-A, REVEL 0.05, CADD 15.70
- P33A (p.Pro33Ala), TOPMed rs1393414427, gnomAD rs1393414427, UniProt VAR 060632, Benign, in allele DPB1*75:01
- P33L (p.Pro33Leu), TOPMed rs1762524376
- P33S (p.Pro33Ser), TOPMed rs1393414427, gnomAD rs1393414427, REVEL 0.11, CADD 18.50
- P33del (p.Pro33del), gnomAD 6-33076135-ACTC-A, CADD 17.10
- P33Q (p.Pro33Gln), gnomAD 6-33076137-TC-T, CADD 24.20
- P33T (p.Pro33Thr), gnomAD 6-33076138-C-A, REVEL 0.04, CADD 20.50
- E34* (p.Glu34Ter), ExAC rs779874572, TOPMed rs779874572, gnomAD rs779874572, CADD 60.00
- E34D (p.Glu34Asp), NCI-TCGA Cosmic COSV6960, Variant assessed as somatic; moderate impact.
- E34K (p.Glu34Lys), ExAC rs779874572, TOPMed rs779874572, gnomAD rs779874572, REVEL 0.11, CADD 26.80
- E34Q (p.Glu34Gln), ExAC rs779874572, TOPMed rs779874572, gnomAD rs779874572, REVEL 0.07, CADD 25.60
- E34G (p.Glu34Gly), gnomAD 6-33080672-A-G, REVEL 0.12, CADD 20.30
- E34E (p.Glu34Glu), gnomAD 6-33080673-G-A, CADD 11.30
- N35K (p.Asn35Lys), rs1255064994, gnomAD 6-33080528-G-GAA, CADD 3.39
- N35I (p.Asn35Ile), gnomAD 6-33080530-A-T, CADD 7.44
- Y36* (p.Tyr36Ter), ExAC rs41544522, TOPMed rs41544522, gnomAD rs41544522, CADD 39.00
- Y36C (p.Tyr36Cys), gnomAD 6-33080678-A-G, REVEL 0.20, CADD 19.50
- p.Tyr36 Leu37insVal, rs751536871, gnomAD 6-33080679-C-CGTG, CADD 12.20
- L37I (p.Leu37Ile), 1000Genomes rs1126504, ESP rs1126504, ExAC rs1126504, TOPMed rs1126504, REVEL 0.17, CADD 12.00, in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, a
- L37P (p.Leu37Pro), Ensembl rs202176660
- L37V (p.Leu37Val), rs1126504, 1000Genomes rs1126504, ESP rs1126504, ExAC rs1126504, REVEL 0.32, CADD 10.70, Benign, in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, a
- L37S (p.Leu37Ser), gnomAD 6-33080679-CCTTT-, CADD 27.10
- L37H (p.Leu37His), gnomAD 6-33080681-T-A, REVEL 0.19, CADD 24.70
- F38D (p.Phe38Asp), UniProt VAR 060635, Benign, in allele DPB1*70:01
- F38H (p.Phe38His), Ensembl rs1762792701, UniProt VAR 060634, Benign, in allele DPB1*09:01, allele DPB1*10:01, allele DPB1*14:01, allele DPB1*16:02, a
- F38L (p.Phe38Leu), TOPMed rs1762793706, gnomAD rs1762793706, REVEL 0.30, CADD 11.60
- F38V (p.Phe38Val), 1000Genomes rs12722013, ExAC rs12722013, gnomAD rs12722013, REVEL 0.17, CADD 13.80
- F38Y (p.Phe38Tyr), rs1126509, 1000Genomes rs1126509, ESP rs1126509, ExAC rs1126509, REVEL 0.23, CADD 0.28, Benign, in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, a
- F38del (p.Phe38del), gnomAD 6-33080682-TTTC-T, CADD 9.32
- F38I (p.Phe38Ile), gnomAD 6-33080683-T-A, REVEL 0.16, CADD 14.30
- F38S (p.Phe38Ser), gnomAD 6-33080684-T-C, REVEL 0.20, CADD 4.49
- Q39* (p.Gln39Ter), Ensembl rs79389600, CADD 40.00
- Q39R (p.Gln39Arg), Ensembl rs1762794161
- Q39T (p.Gln39Thr), gnomAD 6-33080684-T-TCA, CADD 13.70
- G40* (p.Gly40Ter), 1000Genomes rs1126511, ExAC rs1126511, gnomAD rs1126511, CADD 32.00
- G40L (p.Gly40Leu), rs386699869, UniProt VAR 060637, Ensembl rs386699869, Benign, in allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, a
- G40V (p.Gly40Val), rs1126513, UniProt VAR 033434, 1000Genomes rs1126513, ExAC rs1126513, REVEL 0.38, CADD 0.11
- G40A (p.Gly40Ala), gnomAD 6-33080689-GGA-G, CADD 10.70
- R41L (p.Arg41Leu), rs41540313, TOPMed rs41540313, gnomAD rs41540313, UniProt VAR 060638, REVEL 0.20, CADD 16.60, Benign, in allele DPB1*77:01
- R41P (p.Arg41Pro), TOPMed rs41540313, gnomAD rs41540313, REVEL 0.20, CADD 22.50
- R41W (p.Arg41Trp), gnomAD rs1258332221, REVEL 0.14, CADD 17.90
- R41Q (p.Arg41Gln), gnomAD 6-33080693-G-A, REVEL 0.14, CADD 16.80
- Q42N (p.Gln42Asn), rs1554185506, gnomAD 6-33080690-G-GCAG, CADD 10.10
- Q42K (p.Gln42Lys), gnomAD 6-33080695-C-A, REVEL 0.27, CADD 0.00
- E43G (p.Glu43Gly), ExAC rs755441461, gnomAD rs755441461, REVEL 0.09, CADD 24.10
- E43Q (p.Glu43Gln), ExAC rs749490757, gnomAD rs749490757, REVEL 0.16, CADD 21.50
- E43K (p.Glu43Lys), gnomAD 6-33080698-G-A, REVEL 0.23, CADD 22.70
- C44* (p.Cys44Ter), NCI-TCGA Cosmic COSV6960, TOPMed rs1189537940, gnomAD rs1189537940, CADD 23.60, Variant assessed as somatic; high impact., in allele DPB1*26:02
- C44G (p.Cys44Gly), rs1424116907, UniProt VAR 060639, TOPMed rs1424116907, gnomAD rs1424116907, REVEL 0.20, CADD 23.00, Benign, in allele DPB1*26:02
- C44R (p.Cys44Arg), TOPMed rs1424116907, gnomAD rs1424116907, REVEL 0.21, CADD 23.10
- C44C (p.Cys44Cys), rs1421339144, gnomAD 6-33080703-C-T, CADD 10.10
- Y45C (p.Tyr45Cys), TOPMed rs1477548131, gnomAD rs1477548131, REVEL 0.14, CADD 23.00
- Y45Y (p.Tyr45Tyr), rs188627284, gnomAD 6-33080706-C-T, CADD 0.84, SIFT 0.00
- A46P (p.Ala46Pro), rs41555313, UniProt VAR 060640, 1000Genomes rs41555313, ExAC rs41555313, REVEL 0.19, CADD 23.10, Benign, in allele DPB1*38:01
- A46S (p.Ala46Ser), 1000Genomes rs41555313, ExAC rs41555313, TOPMed rs41555313, gnomAD rs41555313, REVEL 0.16, CADD 18.60
- A46T (p.Ala46Thr), rs41555313, 1000Genomes rs41555313, ExAC rs41555313, TOPMed rs41555313, REVEL 0.19, CADD 20.50, Benign, in allele DPB1*18:02
- A46V (p.Ala46Val), Ensembl rs2150372326, NCI-TCGA TCGA novel, Variant assessed as somatic; moderate impact., in allele DPB1*18:02
- A46E (p.Ala46Glu), gnomAD 6-33080708-C-A, REVEL 0.16, CADD 14.80
- N48N (p.Asn48Asn), rs772565701, gnomAD 6-33080715-T-C, CADD 6.49
- G49E (p.Gly49Glu), NCI-TCGA TCGA novel, Variant assessed as somatic; moderate impact.
- G49R (p.Gly49Arg), TOPMed rs1762799257, REVEL 0.25, CADD 22.70
- G49G (p.Gly49Gly), gnomAD 6-33080718-G-A, CADD 10.50
- T50A (p.Thr50Ala), NCI-TCGA TCGA novel, REVEL 0.25, CADD 23.60, Variant assessed as somatic; moderate impact.
- T50I (p.Thr50Ile), Ensembl rs1298055050
- T50R (p.Thr50Arg), gnomAD 6-33080720-C-G, REVEL 0.25, CADD 23.00
- Q51L (p.Gln51Leu), gnomAD 6-33080723-A-T, REVEL 0.23, CADD 22.40
- Q51Q (p.Gln51Gln), rs772611590, gnomAD 6-33080724-G-A, CADD 4.31
- R52C (p.Arg52Cys), gnomAD rs1398087384
- R52H (p.Arg52His), TOPMed rs1377639586, gnomAD rs1377639586
- R52L (p.Arg52Leu), TOPMed rs1377639586, gnomAD rs1377639586
- R52P (p.Arg52Pro), TOPMed rs1377639586, gnomAD rs1377639586, REVEL 0.17, CADD 23.80
- R52R (p.Arg52Arg), gnomAD 6-33080727-C-G, CADD 7.35
- F53Y (p.Phe53Tyr), Ensembl rs2150372380
- L54P (p.Leu54Pro), TOPMed rs1465711975, gnomAD rs1465711975, REVEL 0.16, CADD 23.80
- L54Q (p.Leu54Gln), TOPMed rs1465711975, gnomAD rs1465711975
- L54L (p.Leu54Leu), rs1172051426, gnomAD 6-33080731-C-T, CADD 1.21
- E55D (p.Glu55Asp), ExAC rs776310599, TOPMed rs776310599, gnomAD rs776310599, REVEL 0.33, CADD 0.00
- E55Q (p.Glu55Gln), TOPMed rs934444166, REVEL 0.24, CADD 16.40
- E55V (p.Glu55Val), ExAC rs770346059, TOPMed rs770346059, gnomAD rs770346059, REVEL 0.25, CADD 21.10
- E55E (p.Glu55Glu), rs776310599, gnomAD 6-33080736-G-A, CADD 0.65
Public HLA-DPB1 analysis runs
- HLA-DPB1 analysis run — HLA-DPB1 (585 variants) — completed 2026-08-20