Y45C (p.Tyr45Cys) variant of HLA-DPB1 (P04440)
Y45C (p.Tyr45Cys) in HLA-DPB1 (P04440) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
Y45C (p.Tyr45Cys) variant details
- p.Tyr45Cys
- TOPMed rs1477548131
- gnomAD rs1477548131
- Missense
- Variant Prioritization Score for Impact Estimate 0.187
- REVEL 0.14
- CADD 23.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available