T12R (p.Thr12Arg) variant of HLA-DPB1 (P04440)
T12R (p.Thr12Arg) in HLA-DPB1 (P04440) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data, published literature, and structural context.
T12R (p.Thr12Arg) variant details
- p.Thr12Arg
- gnomAD 6-33076076-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.134
- REVEL 0.13
- CADD 10.60
- PolyPhen-2 0.72
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available