R11G (p.Arg11Gly) variant of HLA-DPB1 (P04440)
R11G (p.Arg11Gly) in HLA-DPB1 (P04440) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data and structural context.
R11G (p.Arg11Gly) variant details
- p.Arg11Gly
- ExAC rs777782877
- TOPMed rs777782877
- gnomAD rs777782877
- NCI-TCGA TCGA novel
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0597
- REVEL 0.04
- CADD 5.39
- PolyPhen-2 0.00
- SIFT 0.13
- UniProt: Variant assessed as somatic; high impact.
- Most common in the HGDP:BALOCHI population (allele frequency 0.022)
- Structural context available