A46S (p.Ala46Ser) variant of HLA-DPB1 (P04440)
A46S (p.Ala46Ser) in HLA-DPB1 (P04440) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
A46S (p.Ala46Ser) variant details
- p.Ala46Ser
- 1000Genomes rs41555313
- ExAC rs41555313
- TOPMed rs41555313
- gnomAD rs41555313
- Missense
- Variant Prioritization Score for Impact Estimate 0.231
- REVEL 0.16
- CADD 18.60
- PolyPhen-2 0.20
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available