T16K (p.Thr16Lys) variant of HLA-DPB1 (P04440)
T16K (p.Thr16Lys) in HLA-DPB1 (P04440) is a missense change. Clinical records from EBI and UniProt describe it as benign in the context of in allele DPB1*09:02. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
T16K (p.Thr16Lys) variant details
- p.Thr16Lys
- 1000Genomes rs41558014
- ESP rs41558014
- ExAC rs41558014
- TOPMed rs41558014
- Benign
- in allele DPB1*09:02
- Missense
- Variant Prioritization Score for Impact Estimate 0.0841
- REVEL 0.11
- CADD 0.01
- PolyPhen-2 0.15
- SIFT 0.09
- EBI: Benign (in allele DPB1*09:02)
- UniProt: Benign (in allele DPB1*09:02)
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available