HLA-DPA1 (P20036) variants and mutations

HLA-DPA1 (also known as P20036) is a human protein-coding gene encoding a HLA class II histocompatibility antigen, DP alpha 1 chain protein. Together with an HLA-DP beta chain, it presents extracellularly derived peptides to CD4 T cells and helps coordinate adaptive immune responses. Allelic variation can modify susceptibility to infection, autoimmunity, and hypersensitivity to selected drugs or environmental antigens. This analysis covers 550 HLA-DPA1 variants and mutations. Of these, 93% have computational variant effect predictions. Disease context includes type 1 diabetes mellitus, neoplasm, and pulmonary arterial hypertension. Example HLA-DPA1 variants include R2C, R2H, and P3L.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable HLA-DPA1 variants

Examples include R2C, R2H, P3L, E4K, D5G, R6G, R6K, M7T. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.