M54L (p.Met54Leu) variant of HLA-DPA1 (P20036)
M54L (p.Met54Leu) in HLA-DPA1 (P20036) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, published literature, and structural context.
M54L (p.Met54Leu) variant details
- p.Met54Leu
- gnomAD 6-33069827-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.204
- REVEL 0.13
- CADD 11.20
- PolyPhen-2 0.01
- SIFT 0.07
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available
- Literature evidence available