L23R (p.Leu23Arg) variant of HLA-DPA1 (P20036)
L23R (p.Leu23Arg) in HLA-DPA1 (P20036) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
L23R (p.Leu23Arg) variant details
- p.Leu23Arg
- ExAC rs778265055
- TOPMed rs778265055
- gnomAD rs778265055
- Missense
- Variant Prioritization Score for Impact Estimate 0.258
- REVEL 0.19
- MetaLR 0.02
- MetaSVM -1.09
- CADD 25.00
- PolyPhen-2 1.00
- SIFT 0.06
- Most common in the REMAINING population (allele frequency 6.6e-05)
- Structural context available