R6G (p.Arg6Gly) variant of HLA-DPA1 (P20036)
R6G (p.Arg6Gly) in HLA-DPA1 (P20036) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
R6G (p.Arg6Gly) variant details
- p.Arg6Gly
- ExAC rs768800135
- gnomAD rs768800135
- Missense
- Variant Prioritization Score for Impact Estimate 0.191
- REVEL 0.07
- MetaLR 0.01
- MetaSVM -0.90
- CADD 23.00
- PolyPhen-2 0.72
- SIFT 0.23
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available