G90R (p.Gly90Arg) variant of HLA-DPA1 (P20036)
G90R (p.Gly90Arg) in HLA-DPA1 (P20036) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
G90R (p.Gly90Arg) variant details
- p.Gly90Arg
- rs1334072731
- TOPMed rs1334072731
- gnomAD rs1334072731
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.274
- REVEL 0.14
- CADD 21.30
- PolyPhen-2 0.29
- SIFT 0.03
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available