L20M (p.Leu20Met) variant of HLA-DPA1 (P20036)
L20M (p.Leu20Met) in HLA-DPA1 (P20036) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
L20M (p.Leu20Met) variant details
- p.Leu20Met
- ExAC rs747858970
- TOPMed rs747858970
- gnomAD rs747858970
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.08
- MetaLR 0.01
- MetaSVM -1.07
- CADD 21.10
- PolyPhen-2 1.00
- SIFT 0.10
- Most common in the Latino/Admixed American population (allele frequency 8.9e-05)
- Structural context available