L97S (p.Leu97Ser) variant of HLA-DPA1 (P20036)
L97S (p.Leu97Ser) in HLA-DPA1 (P20036) is a missense change. Clinical records from EBI and UniProt describe it as benign in the context of in allele DPA1*03:01 and allele DPA1*03:03. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
L97S (p.Leu97Ser) variant details
- p.Leu97Ser
- rs2308917
- 1000Genomes rs2308917
- ESP rs2308917
- ExAC rs2308917
- Benign
- in allele DPA1*03:01 and allele DPA1*03:03
- Missense
- Variant Prioritization Score for Impact Estimate 0.216
- REVEL 0.28
- CADD 7.11
- PolyPhen-2 0.01
- SIFT 0.82
- EBI: Benign (in allele DPA1*03:01 and allele DPA1*03:03)
- UniProt: Benign (in allele DPA1*03:01 and allele DPA1*03:03)
- Most common in the HGDP:MBUTI population (allele frequency 0.88)
- Structural context available