Q81R (p.Gln81Arg) variant of HLA-DPA1 (P20036)
Q81R (p.Gln81Arg) in HLA-DPA1 (P20036) is a missense change. Clinical records from EBI and UniProt describe it as benign in the context of in allele DPA1*01:08, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, a. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data and structural context.
Q81R (p.Gln81Arg) variant details
- p.Gln81Arg
- rs1042178
- 1000Genomes rs1042178
- ESP rs1042178
- ExAC rs1042178
- Benign
- in allele DPA1*01:08, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, a
- Missense
- Variant Prioritization Score for Impact Estimate 0.0609
- REVEL 0.05
- CADD 0.01
- PolyPhen-2 0.00
- SIFT 1.00
- EBI: Benign (in allele DPA1*01:08, allele DPA1*02:01, allele DPA1*02:02, alle)
- UniProt: Benign (in allele DPA1*01:08, allele DPA1*02:01, allele DPA1*02:02, alle)
- Most common in the HGDP:BOUGAINVILLE population (allele frequency 0.91)
- Structural context available