L15W (p.Leu15Trp) variant of HLA-DPA1 (P20036)
L15W (p.Leu15Trp) in HLA-DPA1 (P20036) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
L15W (p.Leu15Trp) variant details
- p.Leu15Trp
- TOPMed rs1364297064
- gnomAD rs1364297064
- Missense
- Variant Prioritization Score for Impact Estimate 0.19
- REVEL 0.11
- MetaLR 0.02
- MetaSVM -1.04
- CADD 20.80
- PolyPhen-2 1.00
- SIFT 0.19
- Most common in the Ashkenazi Jewish population (allele frequency 0.00029)
- Structural context available