E4K (p.Glu4Lys) variant of HLA-DPA1 (P20036)
E4K (p.Glu4Lys) in HLA-DPA1 (P20036) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
E4K (p.Glu4Lys) variant details
- p.Glu4Lys
- gnomAD rs1762392121
- Missense
- Variant Prioritization Score for Impact Estimate 0.106
- REVEL 0.03
- MetaLR 0.00
- MetaSVM -0.93
- CADD 14.90
- PolyPhen-2 0.01
- SIFT 0.22
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available