T46M (p.Thr46Met) variant of HLA-DPA1 (P20036)
T46M (p.Thr46Met) in HLA-DPA1 (P20036) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
T46M (p.Thr46Met) variant details
- p.Thr46Met
- rs371532700
- 1000Genomes rs371532700
- ESP rs371532700
- ExAC rs371532700
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.245
- REVEL 0.07
- CADD 22.10
- PolyPhen-2 0.90
- SIFT 0.07
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:GWD population (allele frequency 0.0087)
- Structural context available