P49L (p.Pro49Leu) variant of HLA-DPA1 (P20036)
P49L (p.Pro49Leu) in HLA-DPA1 (P20036) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
P49L (p.Pro49Leu) variant details
- p.Pro49Leu
- gnomAD 6-33069841-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.213
- REVEL 0.12
- CADD 24.50
- PolyPhen-2 0.97
- SIFT 0.02
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
- Structural context available
- Literature evidence available