T103I (p.Thr103Ile) variant of HLA-DPA1 (P20036)
T103I (p.Thr103Ile) in HLA-DPA1 (P20036) is a missense change. Clinical records from EBI and UniProt describe it as benign in the context of in allele DPA1*04:01. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
T103I (p.Thr103Ile) variant details
- p.Thr103Ile
- rs41559316
- UniProt VAR 058840
- 1000Genomes rs41559316
- ExAC rs41559316
- Benign
- in allele DPA1*04:01
- Missense
- Variant Prioritization Score for Impact Estimate 0.231
- REVEL 0.34
- CADD 0.05
- PolyPhen-2 0.00
- SIFT 1.00
- EBI: Benign (in allele DPA1*04:01)
- UniProt: Benign (in allele DPA1*04:01)
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available