W74C (p.Trp74Cys) variant of HLA-DPA1 (P20036)
W74C (p.Trp74Cys) in HLA-DPA1 (P20036) is a missense change. Clinical records from EBI and UniProt describe it as benign in the context of in allele DPA1*01:10. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
W74C (p.Trp74Cys) variant details
- p.Trp74Cys
- rs72558171
- Ensembl rs72558171
- UniProt VAR 058837
- Benign
- in allele DPA1*01:10
- Missense
- Variant Prioritization Score for Impact Estimate 0.369
- REVEL 0.22
- CADD 26.10
- PolyPhen-2 1.00
- SIFT 0.00
- EBI: Benign (in allele DPA1*01:10)
- UniProt: Benign (in allele DPA1*01:10)
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available