CD8A (P01732) variants and mutations

CD8A (also known as P01732) is a human protein-coding gene encoding a t-cell surface glycoprotein CD8 alpha chain protein. It helps cytotoxic T cells recognize peptide-loaded MHC class I molecules and strengthens T-cell receptor signaling during immune surveillance. Deficiency can impair cytotoxic T-cell responses, while CD8 expression is widely used to identify and characterize cytotoxic lymphocytes. This analysis covers 563 CD8A variants and mutations. Of these, 95% have computational variant effect predictions. Disease context includes tinea unguium, progressive supranuclear palsy, and stroke disorder. Example CD8A variants include A2S, A2T, and A2V.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, ClinGen, MaveDB, LitVar.

Notable CD8A variants

Examples include A2S, A2T, A2V, L3F, L3S, L8F, L9F, L9P. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.