P21L (p.Pro21Leu) variant of CD8A (P01732)
P21L (p.Pro21Leu) in CD8A (P01732) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data.
P21L (p.Pro21Leu) variant details
- p.Pro21Leu
- ExAC rs764996911
- TOPMed rs764996911
- gnomAD rs764996911
- Missense
- Variant Prioritization Score for Impact Estimate 0.206
- REVEL 0.20
- MetaLR 0.33
- MetaSVM -0.72
- CADD 11.30
- PolyPhen-2 0.12
- SIFT 0.07
- Most common in the African/African-American population (allele frequency 0.00031)