D104Y (p.Asp104Tyr) variant of CD8A (P01732)
D104Y (p.Asp104Tyr) in CD8A (P01732) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data.
D104Y (p.Asp104Tyr) variant details
- p.Asp104Tyr
- NCI-TCGA Cosmic COSV5215
- cosmic curated COSV52156
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.242
- REVEL 0.32
- MetaLR 0.27
- MetaSVM -0.40
- CADD 3.06
- PolyPhen-2 0.57
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)