S116L (p.Ser116Leu) variant of CD8A (P01732)
S116L (p.Ser116Leu) in CD8A (P01732) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
S116L (p.Ser116Leu) variant details
- p.Ser116Leu
- rs1165098264
- NCI-TCGA Cosmic COSV5215
- cosmic curated COSV52156
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.347
- REVEL 0.12
- MetaLR 0.20
- MetaSVM -0.91
- CADD 16.50
- PolyPhen-2 0.65
- SIFT 0.14
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available