I122S (p.Ile122Ser) variant of CD8A (P01732)
I122S (p.Ile122Ser) in CD8A (P01732) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
I122S (p.Ile122Ser) variant details
- p.Ile122Ser
- ExAC rs760876561
- TOPMed rs760876561
- gnomAD rs760876561
- Missense
- Variant Prioritization Score for Impact Estimate 0.0923
- REVEL 0.05
- MetaLR 0.07
- MetaSVM -1.00
- CADD 4.87
- PolyPhen-2 0.16
- SIFT 0.11
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available