R88W (p.Arg88Trp) variant of CD8A (P01732)
R88W (p.Arg88Trp) in CD8A (P01732) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data.
R88W (p.Arg88Trp) variant details
- p.Arg88Trp
- TOPMed rs1448570283
- gnomAD rs1448570283
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.232
- REVEL 0.19
- MetaLR 0.48
- MetaSVM -0.91
- CADD 17.30
- PolyPhen-2 0.96
- SIFT 0.12
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 4.8e-05)