S74Y (p.Ser74Tyr) variant of CD8A (P01732)
S74Y (p.Ser74Tyr) in CD8A (P01732) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
S74Y (p.Ser74Tyr) variant details
- p.Ser74Tyr
- cosmic curated COSV52159
- Missense
- Variant Prioritization Score for Impact Estimate 0.226
- REVEL 0.12
- MetaLR 0.40
- MetaSVM -0.90
- CADD 22.30
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available