E82K (p.Glu82Lys) variant of CD8A (P01732)
E82K (p.Glu82Lys) in CD8A (P01732) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
E82K (p.Glu82Lys) variant details
- p.Glu82Lys
- NCI-TCGA Cosmic COSV9937
- cosmic curated COSV99374
- Ensembl rs2104440141
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.138
- REVEL 0.11
- MetaLR 0.23
- MetaSVM -0.81
- CADD 5.63
- PolyPhen-2 0.34
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available