L84P (p.Leu84Pro) variant of CD8A (P01732)
L84P (p.Leu84Pro) in CD8A (P01732) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
L84P (p.Leu84Pro) variant details
- p.Leu84Pro
- rs1056431594
- NCI-TCGA Cosmic COSV5215
- cosmic curated COSV52156
- TOPMed rs1056431594
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.245
- REVEL 0.15
- MetaLR 0.35
- MetaSVM -0.85
- CADD 19.70
- PolyPhen-2 1.00
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available