R25L (p.Arg25Leu) variant of CD8A (P01732)
R25L (p.Arg25Leu) in CD8A (P01732) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
R25L (p.Arg25Leu) variant details
- p.Arg25Leu
- ExAC rs760120446
- TOPMed rs760120446
- gnomAD rs760120446
- Missense
- Variant Prioritization Score for Impact Estimate 0.273
- REVEL 0.21
- MetaLR 0.17
- MetaSVM -0.71
- CADD 22.70
- PolyPhen-2 0.94
- SIFT 0.02
- Most common in the Middle Eastern population (allele frequency 0.0007)
- Structural context available