PDCD1LG2 (Programmed cell death 1 ligand 2) variants and mutations

PDCD1LG2 (also known as Programmed cell death 1 ligand 2) is a human protein-coding gene encoding a programmed cell death 1 ligand 2 protein. By engaging PD-1, it suppresses T-cell receptor signaling and limits immune activation, particularly in antigen-presenting cells and selected tissues. Tumors can exploit this pathway for immune evasion, although its expression is generally more restricted than PD-L1. This analysis covers 1,349 PDCD1LG2 variants and mutations. Of these, 59% have computational variant effect predictions. Disease context includes melanoma, gastrointestinal stromal tumor, and prostate adenocarcinoma. Example PDCD1LG2 variants include I2F, I2L, and I2M.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable PDCD1LG2 variants

Examples include I2F, I2L, I2M, I2N, I2T, F3L, F3S, F3F. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.