L12M (p.Leu12Met) variant of PDCD1LG2 (Programmed cell death 1 ligand 2)
L12M (p.Leu12Met) in PDCD1LG2 (Programmed cell death 1 ligand 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data, published literature, and structural context.
L12M (p.Leu12Met) variant details
- p.Leu12Met
- gnomAD 9-5522580-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.0746
- REVEL 0.01
- AlphaMissense 0.08
- MetaLR 0.01
- MetaSVM -1.00
- CADD 0.24
- PolyPhen-2 0.06
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available