L20V (p.Leu20Val) variant of PDCD1LG2 (Programmed cell death 1 ligand 2)
L20V (p.Leu20Val) in PDCD1LG2 (Programmed cell death 1 ligand 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
L20V (p.Leu20Val) variant details
- p.Leu20Val
- TOPMed rs1820547052
- Missense
- Variant Prioritization Score for Impact Estimate 0.216
- REVEL 0.08
- AlphaMissense 0.11
- MetaLR 0.03
- MetaSVM -1.05
- CADD 16.40
- PolyPhen-2 0.91
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available