IL23A (Interleukin-23 subunit alpha) variants and mutations

IL23A (also known as Interleukin-23 subunit alpha) is a human protein-coding gene encoding an interleukin-23 subunit alpha protein. It combines with p40 to form IL-23, which sustains pathogenic and protective Th17-cell responses at barrier tissues. Excess IL-23 signaling is central to psoriasis and inflammatory bowel disease, making the pathway a major therapeutic target. This analysis covers 478 IL23A variants and mutations. Of these, 98% have computational variant effect predictions. Disease context includes psoriasis, psoriasis vulgaris, and Crohn disease. Example IL23A variants include L2P, L2V, and L2M.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable IL23A variants

Examples include L2P, L2V, L2M, L2L, L2R, G3E, G3R, G3W. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.