L12V (p.Leu12Val) variant of IL23A (Interleukin-23 subunit alpha)
L12V (p.Leu12Val) in IL23A (Interleukin-23 subunit alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
L12V (p.Leu12Val) variant details
- p.Leu12Val
- TOPMed rs1196413532
- gnomAD rs1196413532
- Missense
- Variant Prioritization Score for Impact Estimate 0.318
- REVEL 0.25
- MetaLR 0.25
- MetaSVM -0.59
- CADD 23.00
- PolyPhen-2 0.98
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available