L2P (p.Leu2Pro) variant of IL23A (Interleukin-23 subunit alpha)
L2P (p.Leu2Pro) in IL23A (Interleukin-23 subunit alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
L2P (p.Leu2Pro) variant details
- p.Leu2Pro
- ExAC rs745769997
- TOPMed rs745769997
- gnomAD rs745769997
- Missense
- Variant Prioritization Score for Impact Estimate 0.182
- REVEL 0.04
- MetaLR 0.12
- MetaSVM -0.93
- CADD 22.80
- PolyPhen-2 0.00
- SIFT 0.03
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available