L40I (p.Leu40Ile) variant of IL23A (Interleukin-23 subunit alpha)
L40I (p.Leu40Ile) in IL23A (Interleukin-23 subunit alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
L40I (p.Leu40Ile) variant details
- p.Leu40Ile
- gnomAD rs1479634872
- Missense
- Variant Prioritization Score for Impact Estimate 0.268
- REVEL 0.04
- MetaLR 0.08
- MetaSVM -0.98
- CADD 20.40
- PolyPhen-2 0.01
- SIFT 0.07
- Most common in the Latino/Admixed American population (allele frequency 2.5e-05)
- Structural context available