L2M (p.Leu2Met) variant of IL23A (Interleukin-23 subunit alpha)
L2M (p.Leu2Met) in IL23A (Interleukin-23 subunit alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
L2M (p.Leu2Met) variant details
- p.Leu2Met
- gnomAD 12-56339048-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.207
- REVEL 0.06
- MetaLR 0.08
- MetaSVM -0.99
- CADD 14.90
- PolyPhen-2 0.33
- SIFT 0.03
- Most common in the Finnish in Finland (FIN) population (allele frequency 2.3e-05)
- Structural context available
- Literature evidence available