PARP2 (Poly [ADP-ribose] polymerase 2) variants and mutations

PARP2 (also known as Poly [ADP-ribose] polymerase 2) is a human protein-coding gene encoding a poly [ADP-ribose] polymerase 2 protein. It cooperates with PARP1 in sensing DNA damage and promoting poly(ADP-ribose)-dependent repair, particularly at single-strand breaks. Its activity contributes to the response to PARP inhibitors and to DNA-repair redundancy in cancer cells. This analysis covers 352 PARP2 variants and mutations. Of these, 79% have computational variant effect predictions. Disease context includes ovarian cancer, neoplasm, and breast cancer. Example PARP2 variants include A2T, A2P, and A2G.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable PARP2 variants

Examples include A2T, A2P, A2G, A2V, A2E, A2A, A3S, A3T. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.