P35L (p.Pro35Leu) variant of PARP2 (Poly [ADP-ribose] polymerase 2)
P35L (p.Pro35Leu) in PARP2 (Poly [ADP-ribose] polymerase 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, published literature, and structural context.
P35L (p.Pro35Leu) variant details
- p.Pro35Leu
- gnomAD 14-20344989-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.315
- REVEL 0.17
- AlphaMissense 0.25
- MetaLR 0.00
- MetaSVM -0.18
- CADD 20.80
- PolyPhen-2 0.87
- Population evidence available
- Structural context available
- Literature evidence available